ENHANCEMENT OF PYOCYANIN PRODUCTION BY SUBINHIBITORY CONCENTRATION OF ROYAL JELLY IN PSEUDOMONAS AERUGINOSA [VERSION 3; PEER REVIEW: 2 APPROVED, 1 APPROVED WITH RESERVATIONS]

Enhancement of pyocyanin production by subinhibitory concentration of royal jelly in Pseudomonas aeruginosa [version 3; peer review: 2 approved, 1 approved with reservations]

Background: Pseudomonas aeruginosa, a multidrug-resistant Gram-negative bacterium, produces pyocyanin, a virulence factor associated with antibiotic tolerance.High concentrations of royal jelly have an antibacterial effect, which may potentially overcome antibacterial resistance.However, in some cases, antibiotic tolerance can occur due to prolonge

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Malignant syphilis as the first manifestation of HIV infection

Malignant syphilis is a rare and severe variant of secondary syphilis.It is clinically characterized by large papular, nodular and ulcerative lesions affecting the trunk and the extremities and covered Dog Tag Necklace Gift Box with thick crust.We present a case of 52-year-old homosexual male who developed malignant syphilis and this was the first

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Bone marrow-targetable Green Tea Catechin-Based Micellar Nanocomplex for synergistic therapy of Acute myeloid leukemia

Abstract Background Currently available anti-leukemia drugs have shown limited success in the treatment of acute myeloid leukemia (AML) due to their poor access to bone marrow niche supporting leukemic cell proliferation.Results Herein, we report Transit Bolt a bone marrow-targetable green tea catechin-based micellar nanocomplex for synergistic AML

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